REGULAR CONTENT
Final ID
620
Type
Educational Exhibit-Poster Only
Authors
D Szaflarski1, N Azimov1, A Eweka1, J Schneider1, J Hoffmann2
Institutions
1Winthrop-University Hospital, Mineola, NY, 2WInthrop-University Hospital, Mineola, NY
Purpose
1. Review the concept of the abscopal effect and current literature on this topic.2. Detail available literature on the role of interventional radiology (IR) in inducing the abscopal effect.3. Suggest future IR-related studies that are needed to further understand this phenomenon and explore the potential role of IR in inducing this effect.
Materials & Methods
The abscopal effect was first described by R.H. Mole in 1953 as the effect of radiation at a distance away from the irradiated field but within the same organism. Currently, this effect has gained more interest in the oncologic community, as it refers to systemic response of tumors from a localized treatment of one tumor. With recent advances in immunotherapy, there is increased interest in various targeted therapies that may be used with immunotherapy to improve systemic responses with the goal of achieving the abscopal effect.
Results
The abscopal effect is likely an immune-mediated phenomenon. A targeted therapy (the most commonly described is local radiation therapy) causes tumor cell death, which then is followed by a systemic immune system response. Thus, a focal therapy may stimulate the immune system to fight other sights of cancer in the body. It is currently thought that T-cells and dendritic cells play the primary role. This exhibit thoroughly reviews the abscopal effect, mechanism of action, available literature on the topic (including medical oncology, radiation oncology, and interventional oncology), and suggests future IR-related studies involving ablation and/or embolization that are needed to better understand this phenomenon. With the increased use of immunotherapy, studying the addition of local ablative therapies to achieve increased rates of the abscopal effect is warranted.
Conclusions
Combining local ablative therapies with immunotherapy may lead improved systemic responses and increased rates of achieving the abscopal effect. Additional research from the medical oncology and interventional oncology community is needed to study this further.
Final ID
620
Type
Educational Exhibit-Poster Only
Authors
D Szaflarski1, N Azimov1, A Eweka1, J Schneider1, J Hoffmann2
Institutions
1Winthrop-University Hospital, Mineola, NY, 2WInthrop-University Hospital, Mineola, NY
Purpose
1. Review the concept of the abscopal effect and current literature on this topic.2. Detail available literature on the role of interventional radiology (IR) in inducing the abscopal effect.3. Suggest future IR-related studies that are needed to further understand this phenomenon and explore the potential role of IR in inducing this effect.
Materials & Methods
The abscopal effect was first described by R.H. Mole in 1953 as the effect of radiation at a distance away from the irradiated field but within the same organism. Currently, this effect has gained more interest in the oncologic community, as it refers to systemic response of tumors from a localized treatment of one tumor. With recent advances in immunotherapy, there is increased interest in various targeted therapies that may be used with immunotherapy to improve systemic responses with the goal of achieving the abscopal effect.
Results
The abscopal effect is likely an immune-mediated phenomenon. A targeted therapy (the most commonly described is local radiation therapy) causes tumor cell death, which then is followed by a systemic immune system response. Thus, a focal therapy may stimulate the immune system to fight other sights of cancer in the body. It is currently thought that T-cells and dendritic cells play the primary role. This exhibit thoroughly reviews the abscopal effect, mechanism of action, available literature on the topic (including medical oncology, radiation oncology, and interventional oncology), and suggests future IR-related studies involving ablation and/or embolization that are needed to better understand this phenomenon. With the increased use of immunotherapy, studying the addition of local ablative therapies to achieve increased rates of the abscopal effect is warranted.
Conclusions
Combining local ablative therapies with immunotherapy may lead improved systemic responses and increased rates of achieving the abscopal effect. Additional research from the medical oncology and interventional oncology community is needed to study this further.