REGULAR CONTENT
Final ID
588
Type
Educational Exhibit-Poster Only
Authors
W Ye1, S Athreya2
Institutions
1Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, 2St. Joseph's Healthcare, Hamilton, ON
Purpose
To perform a systemic literature review on the usage of transcatheter arterial embolization (TAE) to reduce renal volume prior to kidney transplantation, and to relief compression symptoms in adult dominant polycystic kidney disease (ADPKD).
Materials & Methods
ADPKD is an autosomal dominant disorder that affects approximately 1 in every 400 – 1000 live births. ADPKD accounts for 5% of patients on dialysis in the United States, and 50% of patients with ADPKD will develop renal insufficiency requiring dialysis. Individuals present with increased renal volume measured on abdominal CT: increased renal volume has been shown to be prognostic of renal insufficiency risk. Due to increase in renal volume, patients who require kidney transplantation must reduce renal volume in order to increase room in the pelvic area, and decrease symptoms associated with compression. In this systematic review, we look at the efficiency of TAE in treating symptomatically enlarged kidneys to relieve compression symptoms, and to decrease renal size prior to transplantation.
Results
PubMed, Web of Science, and Cochrane Library were searched for articles focused on the usage of TAE to reduce renal volume in symptomatic enlarged kidneys or prior to kidney transplantation. Literature reviews and case reports were excluded from analysis. Renal volume data were compiled, and meta-analysis was performed where applicable. Six papers in total satisfied the inclusion and exclusion criteria: four of which were retrospective chart review studies, and two were prospective observational studies. Significant renal volume reduction was observed by 12 months in all studies. Success of TAE was measured by removal of contraindication for renal transplant in two studies, and relief of compression symptom in three studies. Proportionality meta-analysis of three studies measuring relief of compression symptoms showed no significant differences in heterogeneity (p=0.2775).
Conclusions
Overall, current studies conclude that TAE is an effective, and minimally invasive alternative to nephrectomy in reduction of renal volume and for relief of compression symptoms.
Final ID
588
Type
Educational Exhibit-Poster Only
Authors
W Ye1, S Athreya2
Institutions
1Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, 2St. Joseph's Healthcare, Hamilton, ON
Purpose
To perform a systemic literature review on the usage of transcatheter arterial embolization (TAE) to reduce renal volume prior to kidney transplantation, and to relief compression symptoms in adult dominant polycystic kidney disease (ADPKD).
Materials & Methods
ADPKD is an autosomal dominant disorder that affects approximately 1 in every 400 – 1000 live births. ADPKD accounts for 5% of patients on dialysis in the United States, and 50% of patients with ADPKD will develop renal insufficiency requiring dialysis. Individuals present with increased renal volume measured on abdominal CT: increased renal volume has been shown to be prognostic of renal insufficiency risk. Due to increase in renal volume, patients who require kidney transplantation must reduce renal volume in order to increase room in the pelvic area, and decrease symptoms associated with compression. In this systematic review, we look at the efficiency of TAE in treating symptomatically enlarged kidneys to relieve compression symptoms, and to decrease renal size prior to transplantation.
Results
PubMed, Web of Science, and Cochrane Library were searched for articles focused on the usage of TAE to reduce renal volume in symptomatic enlarged kidneys or prior to kidney transplantation. Literature reviews and case reports were excluded from analysis. Renal volume data were compiled, and meta-analysis was performed where applicable. Six papers in total satisfied the inclusion and exclusion criteria: four of which were retrospective chart review studies, and two were prospective observational studies. Significant renal volume reduction was observed by 12 months in all studies. Success of TAE was measured by removal of contraindication for renal transplant in two studies, and relief of compression symptom in three studies. Proportionality meta-analysis of three studies measuring relief of compression symptoms showed no significant differences in heterogeneity (p=0.2775).
Conclusions
Overall, current studies conclude that TAE is an effective, and minimally invasive alternative to nephrectomy in reduction of renal volume and for relief of compression symptoms.