REGULAR CONTENT
Final ID
545
Type
Original Scientific Research-Oral or Pos
Authors
R Mushtaq1, A JANICEK1, P Ho1, H Markus2, S Black1, G Woodhead1, P Devis1, C Hennemeyer1
Institutions
1University of Arizona, Tucson, AZ, 2Arizona State University, Tempe, AZ
Purpose
Platelet abnormalities are a common complication of chronic liver disease. The underlying etiology for these abnormalities is still unclear; though, it has been postulated that portal hypertension with subsequent hypersplenism can result in splenic pooling and destruction of platelets. The aim of this study was to determine if correction of portal hypertension via transjugular intrahepatic portosystemic shunt (TIPS) procedure correlated with reversal of cirrhosis associated thrombocytopenia.
Materials & Methods
Patients undergoing elective or emergent TIPS at a tertiary institution, between June 2012 and June 2016, were retrospectively analyzed. Seventy three patients met the inclusion criteria. Pre-procedure and post-procedure platelet counts and mean platelet volume were obtained at the following intervals: preoperative; 1 month, 3 months, 6 months, 12 months, 24 months and 36 months.
Results
There was a statistically significant difference between mean pre- (16.48 ± 6.66 mmHg) and post- (7.71 ± 3.58 mmHg) portal venous pressure gradient (p=3.004e-09). The mean pre-procedural platelet count was 119. Post-TIPS platelet count varied with no significant observable trend. In subgroup analysis, patients that underwent emergent TIPS for uncontrolled gastrointestinal bleed showed a decreased mean platelet count of 81 at six months as compared to the pre-TIPS platelet count (p=0.035).
Conclusions
Reduction in portal hypertension through TIPS did not correlate with correction of thrombocytopenia associated with chronic liver disease. Significant post-procedure reduction in platelet count was observed in emergent gastrointestinal bleeds at 6 months; however, this was found in a small number of patients and requires further evaluation.
Final ID
545
Type
Original Scientific Research-Oral or Pos
Authors
R Mushtaq1, A JANICEK1, P Ho1, H Markus2, S Black1, G Woodhead1, P Devis1, C Hennemeyer1
Institutions
1University of Arizona, Tucson, AZ, 2Arizona State University, Tempe, AZ
Purpose
Platelet abnormalities are a common complication of chronic liver disease. The underlying etiology for these abnormalities is still unclear; though, it has been postulated that portal hypertension with subsequent hypersplenism can result in splenic pooling and destruction of platelets. The aim of this study was to determine if correction of portal hypertension via transjugular intrahepatic portosystemic shunt (TIPS) procedure correlated with reversal of cirrhosis associated thrombocytopenia.
Materials & Methods
Patients undergoing elective or emergent TIPS at a tertiary institution, between June 2012 and June 2016, were retrospectively analyzed. Seventy three patients met the inclusion criteria. Pre-procedure and post-procedure platelet counts and mean platelet volume were obtained at the following intervals: preoperative; 1 month, 3 months, 6 months, 12 months, 24 months and 36 months.
Results
There was a statistically significant difference between mean pre- (16.48 ± 6.66 mmHg) and post- (7.71 ± 3.58 mmHg) portal venous pressure gradient (p=3.004e-09). The mean pre-procedural platelet count was 119. Post-TIPS platelet count varied with no significant observable trend. In subgroup analysis, patients that underwent emergent TIPS for uncontrolled gastrointestinal bleed showed a decreased mean platelet count of 81 at six months as compared to the pre-TIPS platelet count (p=0.035).
Conclusions
Reduction in portal hypertension through TIPS did not correlate with correction of thrombocytopenia associated with chronic liver disease. Significant post-procedure reduction in platelet count was observed in emergent gastrointestinal bleeds at 6 months; however, this was found in a small number of patients and requires further evaluation.