REGULAR CONTENT
Final ID
543
Type
Original Scientific Research-Oral or Pos
Authors
A Kamel Abdel Aal1, S Kim2, M Babi1, M Massoud1, S Moawad1, B Jackson1, A Moustafa3, S Saddekni2
Institutions
1University of Alabama at Birmingham (UAB), Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3University of Alabama At Birmingham (UAB), Birmingham, AL
Purpose
Platelet count is an important laboratory metric that reflects the change in portal pressure after transjugular intrahepatic portosystemic shunt (TIPS) placement. However, the increase in platelet count after TIPS placement is variable between patients. The purpose of this study is to demonstrate if there is a correlation between the changes in platelet count after TIPS with the change in portosystemic pressure gradient (PSG).
Materials & Methods
We retrospectively reviewed the medical records of 306 patients who had TIPS placed between January 2004 and December 2015. We stratified the patients into 4 groups according to the pre-TIPS platelet count: group1 (0-20), group2 (20-50), group3 (50-100), group4 (100-150). We calculated the percent change in platelet count before and after TIPS as well as the percent change in PSG for each group.
Results
The study included 193 (63%) males and 113 (37%) females, 208 Caucasians (68%), with a mean age of 56.6 years. There was an overall increase in the platelet count after TIPS (mean=17%, SD=62%). When the patients were stratified according to their pre-TIPS platelet counts, the percent change in the platelet count was statistically significantly different by pair wise comparison between the groups (p<0.05), with patients in groups 1,2,3 and 4 showing a mean of 243%, 59%, 25% and 0.26% increase in platelet counts respectively. There was a negative correlation between the change in the platelet count and the change in PSG which decreased after TIPS (mean=67%, SD=17%). This negative correlation was maintained when the patients were stratified into groups, despite the fact that the change in the PSG was not statistically significantly different between the groups.
Conclusions
Pre-TIPS platelet count is an important indicator for the improvement in platelet count after TIPS. The change in the platelet count correlates with the change in PSG, and can be used as an indicator for improvement of PSG after TIPS.
Final ID
543
Type
Original Scientific Research-Oral or Pos
Authors
A Kamel Abdel Aal1, S Kim2, M Babi1, M Massoud1, S Moawad1, B Jackson1, A Moustafa3, S Saddekni2
Institutions
1University of Alabama at Birmingham (UAB), Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3University of Alabama At Birmingham (UAB), Birmingham, AL
Purpose
Platelet count is an important laboratory metric that reflects the change in portal pressure after transjugular intrahepatic portosystemic shunt (TIPS) placement. However, the increase in platelet count after TIPS placement is variable between patients. The purpose of this study is to demonstrate if there is a correlation between the changes in platelet count after TIPS with the change in portosystemic pressure gradient (PSG).
Materials & Methods
We retrospectively reviewed the medical records of 306 patients who had TIPS placed between January 2004 and December 2015. We stratified the patients into 4 groups according to the pre-TIPS platelet count: group1 (0-20), group2 (20-50), group3 (50-100), group4 (100-150). We calculated the percent change in platelet count before and after TIPS as well as the percent change in PSG for each group.
Results
The study included 193 (63%) males and 113 (37%) females, 208 Caucasians (68%), with a mean age of 56.6 years. There was an overall increase in the platelet count after TIPS (mean=17%, SD=62%). When the patients were stratified according to their pre-TIPS platelet counts, the percent change in the platelet count was statistically significantly different by pair wise comparison between the groups (p<0.05), with patients in groups 1,2,3 and 4 showing a mean of 243%, 59%, 25% and 0.26% increase in platelet counts respectively. There was a negative correlation between the change in the platelet count and the change in PSG which decreased after TIPS (mean=67%, SD=17%). This negative correlation was maintained when the patients were stratified into groups, despite the fact that the change in the PSG was not statistically significantly different between the groups.
Conclusions
Pre-TIPS platelet count is an important indicator for the improvement in platelet count after TIPS. The change in the platelet count correlates with the change in PSG, and can be used as an indicator for improvement of PSG after TIPS.