REGULAR CONTENT
Final ID
508
Type
Original Scientific Research-Oral or Pos
Authors
N Fatemi1, A Lee2, J Kessler3, J Park4
Institutions
1City of Hope, Duarte, CA, 2CITY OF HOPE MEDICAL CENTER, Duarte, CA, 3City of Hope National Medical Center, Duarte, CA, 4City of Hope Medical Center, Duarte, CA
Purpose
In this study we are examining the risk of infection among patients with history of prior biliary intervention/surgery undergoing radioembolization with Yttrium 90 (Y90) microspheres.
Materials & Methods
We retrospectively reviewed patients with primary or metastatic hepatic cancer treated with Y90 microsphere radioembolization from 2011-2016 in a single institution. Patients with prior surgical or endoscopic biliary intervention (incompetent Sphincter of Oddi) were identified. All demographic data, procedural details, and treatment outcomes were reviewed.
Results
Of 251 patients (394 procedures) who underwent Y90, 12 patients (9M, 3F) had prior biliary intervention. Mean age was 62.6 years (range from 38-80 years). Tumor types included cholangiocarcinoma (n = 6), metastatic neuroendocrine cancer (n = 2), metastatic colorectal cancer (n = 2), metastatic pancreatic cancer (n = 1), and hepatocellular carcinoma (n=1). Prior biliary biliary interventions included Whipple surgery (n=2) prior to radioembolization, Roux-en-Y surgery (n=1), and ERCP with or without stent placement (n = 9). A total of 19 Y90 procedures were performed on these patients with prior biliary intervention; the patients were placed on antibiotic prophylaxis one week before and two weeks after the procedure. The patients were followed from 1 month to 1 year. During this time, no patients developed liver abscesses. No other major procedure related complications were identified.
Conclusions
Our initial study suggests that there is a very low risk of infectious liver complications from Y90 radioembolization in patients with altered biliary anatomy from prior surgery or endoscopy with appropriate antibiotic prophylaxis.
Final ID
508
Type
Original Scientific Research-Oral or Pos
Authors
N Fatemi1, A Lee2, J Kessler3, J Park4
Institutions
1City of Hope, Duarte, CA, 2CITY OF HOPE MEDICAL CENTER, Duarte, CA, 3City of Hope National Medical Center, Duarte, CA, 4City of Hope Medical Center, Duarte, CA
Purpose
In this study we are examining the risk of infection among patients with history of prior biliary intervention/surgery undergoing radioembolization with Yttrium 90 (Y90) microspheres.
Materials & Methods
We retrospectively reviewed patients with primary or metastatic hepatic cancer treated with Y90 microsphere radioembolization from 2011-2016 in a single institution. Patients with prior surgical or endoscopic biliary intervention (incompetent Sphincter of Oddi) were identified. All demographic data, procedural details, and treatment outcomes were reviewed.
Results
Of 251 patients (394 procedures) who underwent Y90, 12 patients (9M, 3F) had prior biliary intervention. Mean age was 62.6 years (range from 38-80 years). Tumor types included cholangiocarcinoma (n = 6), metastatic neuroendocrine cancer (n = 2), metastatic colorectal cancer (n = 2), metastatic pancreatic cancer (n = 1), and hepatocellular carcinoma (n=1). Prior biliary biliary interventions included Whipple surgery (n=2) prior to radioembolization, Roux-en-Y surgery (n=1), and ERCP with or without stent placement (n = 9). A total of 19 Y90 procedures were performed on these patients with prior biliary intervention; the patients were placed on antibiotic prophylaxis one week before and two weeks after the procedure. The patients were followed from 1 month to 1 year. During this time, no patients developed liver abscesses. No other major procedure related complications were identified.
Conclusions
Our initial study suggests that there is a very low risk of infectious liver complications from Y90 radioembolization in patients with altered biliary anatomy from prior surgery or endoscopy with appropriate antibiotic prophylaxis.