REGULAR CONTENT
Final ID
479
Type
Original Scientific Research-Oral or Pos
Authors
T Kim1, E Petre2, M Maybody3, J Durack1, L Brody3, J Erinjeri3, F Boas1, H Yarmohammadi3, S Solomon4, E Ziv1
Institutions
1Memorial Sloan Kettering Cancer Center, New York, NY, 2N/A, United States, 3Memorial Sloan-Kettering Cancer Center, New York, NY, 4N/A, New York, NY
Purpose
To evaluate the extent to which histologic subtypes identified in lung core biopsies can predict prognosis after surgical resection of lung adenocarcinoma.
Materials & Methods
This is an Institutional Review Board approved retrospective study that included consecutive patients from 1/2014 to 12/2015 with a primary diagnosis of lung adenocarcinoma that underwent core needle biopsy followed by surgical resection of their tumor (n=249). Histologic subtypes identified from core needle biopsies were lepidic, acinar, papillary, micropapillary, solid, colloid, mucinous, and cribiform. Pulmonary and distant metastatic progression after surgery was assessed from radiological imaging, clinical notes and pathology reports. Time to progression (TTP) was calculated from the time of resection to documented progression, or last followup without progression. Patients without radiological/clinical follow-up after resection were excluded from the survival analysis (n=13). Histological subtypes identified in the core biopsy were analyzed in relation to TTP, using univariate and multivariate analyses.
Results
In univariate analysis, the lepidic subtype was significantly associated with longer TTP (subdistribution hazard ration [sHR]=0.23, p=0.0058, CI=0.0813-0.653). Conversely, micropapillary (HR=4.14, p=0.00035, CI=1.9-9.03) and mucinous (sHR=3.26, p=0.011, CI=1.31-8.11) tumors were significantly associated with shorter TTP. Solid tumors were marginally associated with TTP (sHR=2.08, p=0.088, CI=0.897-4.82). In multivariate analysis, micropapillary (sHR=3.297 p=0.0037, CI=1.472-7.38) and mucinous (sHR=3.224, p=0.019, CI=1.212-8.57) tumors were independent predictors of shorter TTP. Lepidic tumors were marginally significant (sHR=0.381, p=0.089, CI=0.125-1.16).
Conclusions
Histologic subtypes based on core biopsies can be used to predict progression after surgery for lung adenocarcinoma. Tumors with micropapillary or mucinous characteristics were significantly associated with TTP after resection of lung adenocarcinoma.
Final ID
479
Type
Original Scientific Research-Oral or Pos
Authors
T Kim1, E Petre2, M Maybody3, J Durack1, L Brody3, J Erinjeri3, F Boas1, H Yarmohammadi3, S Solomon4, E Ziv1
Institutions
1Memorial Sloan Kettering Cancer Center, New York, NY, 2N/A, United States, 3Memorial Sloan-Kettering Cancer Center, New York, NY, 4N/A, New York, NY
Purpose
To evaluate the extent to which histologic subtypes identified in lung core biopsies can predict prognosis after surgical resection of lung adenocarcinoma.
Materials & Methods
This is an Institutional Review Board approved retrospective study that included consecutive patients from 1/2014 to 12/2015 with a primary diagnosis of lung adenocarcinoma that underwent core needle biopsy followed by surgical resection of their tumor (n=249). Histologic subtypes identified from core needle biopsies were lepidic, acinar, papillary, micropapillary, solid, colloid, mucinous, and cribiform. Pulmonary and distant metastatic progression after surgery was assessed from radiological imaging, clinical notes and pathology reports. Time to progression (TTP) was calculated from the time of resection to documented progression, or last followup without progression. Patients without radiological/clinical follow-up after resection were excluded from the survival analysis (n=13). Histological subtypes identified in the core biopsy were analyzed in relation to TTP, using univariate and multivariate analyses.
Results
In univariate analysis, the lepidic subtype was significantly associated with longer TTP (subdistribution hazard ration [sHR]=0.23, p=0.0058, CI=0.0813-0.653). Conversely, micropapillary (HR=4.14, p=0.00035, CI=1.9-9.03) and mucinous (sHR=3.26, p=0.011, CI=1.31-8.11) tumors were significantly associated with shorter TTP. Solid tumors were marginally associated with TTP (sHR=2.08, p=0.088, CI=0.897-4.82). In multivariate analysis, micropapillary (sHR=3.297 p=0.0037, CI=1.472-7.38) and mucinous (sHR=3.224, p=0.019, CI=1.212-8.57) tumors were independent predictors of shorter TTP. Lepidic tumors were marginally significant (sHR=0.381, p=0.089, CI=0.125-1.16).
Conclusions
Histologic subtypes based on core biopsies can be used to predict progression after surgery for lung adenocarcinoma. Tumors with micropapillary or mucinous characteristics were significantly associated with TTP after resection of lung adenocarcinoma.