REGULAR CONTENT
Final ID
468
Type
Original Scientific Research-Oral or Pos
Authors
A Cubre1, R Nelson2, D Sopko2, C Kim2
Institutions
1Duke University Hospital, Durham, NC, 2Duke University Medical Center, Durham, NC
Purpose
While percutaneous cryoablation is an accepted minimally invasive treatment for small renal cell carcinoma (RCC), partial nephrectomy remains the preferred nephron-sparing treatment within all societal guidelines. Although local tumor control rates are similar within the literature, guidelines uniformly cite a lack of long-term data on percutaneous renal cryoablation as the reason for downgrading its appropriateness, which is likely related to the older age and higher comorbidities in this selected patient population. The purpose of this study was to evaluate the long-term tumor control rates with percutaneous cryoablation for suspected RCC.
Materials & Methods
Retrospective review of our procedural database from 2005 to 2013 revealed 246 cryoablation procedures for suspected RCC. Patient with known Von Hippel Lindau, >3 RCC's, or biopsy-proven benign pathology were excluded. Only patients with 3 or more years of imaging follow up were included for analysis, resulting in 76 patients (mean age 64.6 years, 53 males, 23 females). Demographics, tumor size, evidence of local recurrence were culled from the imaging archive and electronic medical records.
Results
Limiting the analyzed patient population to 3+ years of imaging follow up, the median imaging follow-up duration was 5.2 years. The median tumor size was 2.1cm (range 1.1-4.7cm). Five patients had local recurrence on imaging, resulting in a local tumor control rate of 93%. The median interval from ablation to detection of recurrence was 24.3 months (range 4.9 – 36.1 months). The mean diameter of these ablated lesions was recurrence was 2.4cm (range 1.6-3.3cm). Four of these lesions were completely endophytic at the time of ablation.
Conclusions
Percutaneous renal cryoablation demonstrated a high local tumor control rate based on long-term imaging surveillance, which is similar to the known short term local tumor control rate. These data suggest that percutaneous cryoablation provides durable tumoral control.
Final ID
468
Type
Original Scientific Research-Oral or Pos
Authors
A Cubre1, R Nelson2, D Sopko2, C Kim2
Institutions
1Duke University Hospital, Durham, NC, 2Duke University Medical Center, Durham, NC
Purpose
While percutaneous cryoablation is an accepted minimally invasive treatment for small renal cell carcinoma (RCC), partial nephrectomy remains the preferred nephron-sparing treatment within all societal guidelines. Although local tumor control rates are similar within the literature, guidelines uniformly cite a lack of long-term data on percutaneous renal cryoablation as the reason for downgrading its appropriateness, which is likely related to the older age and higher comorbidities in this selected patient population. The purpose of this study was to evaluate the long-term tumor control rates with percutaneous cryoablation for suspected RCC.
Materials & Methods
Retrospective review of our procedural database from 2005 to 2013 revealed 246 cryoablation procedures for suspected RCC. Patient with known Von Hippel Lindau, >3 RCC's, or biopsy-proven benign pathology were excluded. Only patients with 3 or more years of imaging follow up were included for analysis, resulting in 76 patients (mean age 64.6 years, 53 males, 23 females). Demographics, tumor size, evidence of local recurrence were culled from the imaging archive and electronic medical records.
Results
Limiting the analyzed patient population to 3+ years of imaging follow up, the median imaging follow-up duration was 5.2 years. The median tumor size was 2.1cm (range 1.1-4.7cm). Five patients had local recurrence on imaging, resulting in a local tumor control rate of 93%. The median interval from ablation to detection of recurrence was 24.3 months (range 4.9 – 36.1 months). The mean diameter of these ablated lesions was recurrence was 2.4cm (range 1.6-3.3cm). Four of these lesions were completely endophytic at the time of ablation.
Conclusions
Percutaneous renal cryoablation demonstrated a high local tumor control rate based on long-term imaging surveillance, which is similar to the known short term local tumor control rate. These data suggest that percutaneous cryoablation provides durable tumoral control.