REGULAR CONTENT
Final ID
463
Type
Original Scientific Research-Oral or Pos
Authors
S Young1, T Sanghvi2, N Hoven2, C Dietz2
Institutions
1University of Minnesota, Edina, MN, 2University of Minnesota, Minnespolis, MN
Purpose
Thyroid cancer is the most common endocrine malignancy and papillary thyroid cancer is the most common histologic type of thyroid cancer. While traditional therapy includes surgery, Iodine 131 (I131) treatment, and external beam radiation, some patients experience recurrence in the form of head and neck lymphadenopathy. When reoccurrences occur in the lymph nodes of the head and neck region repeated surgeries are associated with significant morbidity. This has lead previous authors to examine using ethanol ablation of lymph node recurrence. Unfortunately, the available data in this area is still very limited with only a few small patient cohorts available. The aim of this project is to retrospectively review outcomes of patients with thyroid cancer reoccurrence in head and neck lymph nodes treated with ethanol ablation.
Materials & Methods
This study was approved by our institutional IRB. We retrospectively reviewed 17 patients who underwent ethanol ablation of 32 different lymph nodes for metastatic thyroid cancer at a single academic medical center. The patients charts were evaluated for prior treatment related variables, clinical outcomes, and complications.
Results
All patients had undergone prior I131 therapy and thyroid resections with the mean number of surgeries being 1.58 (range 1-4). The mean number of ethanol ablation treatments per lymph node was 1.94 (range 1-6). Of the 32 lymph nodes all demonstrated local treatment response and disease control. Six of seventeen patients (35%) suffered distal recurrence. One patient demonstrated a major complication of laryngeal paralysis secondary to recurrent laryngeal nerve injury. No minor complications were reported.
Conclusions
Ethanol ablation of metastatic lymph nodes from thyroid cancer is a promising treatment strategy with reduced associated morbidity as compared to surgery. While local disease control seems possible it is as of yet known how effective this strategy will be on long term survival outcomes.
Final ID
463
Type
Original Scientific Research-Oral or Pos
Authors
S Young1, T Sanghvi2, N Hoven2, C Dietz2
Institutions
1University of Minnesota, Edina, MN, 2University of Minnesota, Minnespolis, MN
Purpose
Thyroid cancer is the most common endocrine malignancy and papillary thyroid cancer is the most common histologic type of thyroid cancer. While traditional therapy includes surgery, Iodine 131 (I131) treatment, and external beam radiation, some patients experience recurrence in the form of head and neck lymphadenopathy. When reoccurrences occur in the lymph nodes of the head and neck region repeated surgeries are associated with significant morbidity. This has lead previous authors to examine using ethanol ablation of lymph node recurrence. Unfortunately, the available data in this area is still very limited with only a few small patient cohorts available. The aim of this project is to retrospectively review outcomes of patients with thyroid cancer reoccurrence in head and neck lymph nodes treated with ethanol ablation.
Materials & Methods
This study was approved by our institutional IRB. We retrospectively reviewed 17 patients who underwent ethanol ablation of 32 different lymph nodes for metastatic thyroid cancer at a single academic medical center. The patients charts were evaluated for prior treatment related variables, clinical outcomes, and complications.
Results
All patients had undergone prior I131 therapy and thyroid resections with the mean number of surgeries being 1.58 (range 1-4). The mean number of ethanol ablation treatments per lymph node was 1.94 (range 1-6). Of the 32 lymph nodes all demonstrated local treatment response and disease control. Six of seventeen patients (35%) suffered distal recurrence. One patient demonstrated a major complication of laryngeal paralysis secondary to recurrent laryngeal nerve injury. No minor complications were reported.
Conclusions
Ethanol ablation of metastatic lymph nodes from thyroid cancer is a promising treatment strategy with reduced associated morbidity as compared to surgery. While local disease control seems possible it is as of yet known how effective this strategy will be on long term survival outcomes.