REGULAR CONTENT
Final ID
426
Type
Original Scientific Research-Poster Only
Authors
G Garategui1, M Onorati2, E Becher1, O Peralta3, R Garcia-Monaco4
Institutions
1Italian Hospital of Buenos Aires, Buenos Aires, CABA, 2Buenos Aires University, Buenos Aires, CABA, 3N/A, Buenos Aires, Argentina, 4Hospital Italiano De Buenos Aires, Buenos Aires, Argentina
Purpose
BackgroundThe Benign Prostatic Hyperplasia (BPH) is one of the most common disease in older men that can produce lower urinary tract symptoms (LUTS). In the last years, the Prostatic Arterial Embolization (PAE) gained relevance as a new and potential minimally invasive treatment. Nowadays there are not consensus about of the size of the embolization particle due to the lack of information about the caliber of the prostatic vessels. ObjectiveTo describe the microvasculature of the prostate gland and determine the caliber of the vessels, highlighting implications for the PAE in the BPH.
Materials & Methods
Eighteen adult cadaveric prostate gland with BPH were fixated in formaldehyde and processed histologically in three parts (superior, middle and inferior part). We focus only the parts of the gland that involves the transitional zone. Every sample was stained with hematoxylin and eosin, Masson trichrome and immunoperoxidase to highlight the vessels architecture. We analyzed the diameter of the vessels using Nikon Eclipse E400 Microscope, Nikkon DS-Fi1 Camera and Image J digital software. We classified three kind of vessels in relationship with de nodules of prostatic hyperplasia (NPH): the internodal, the perinodal and the intranodal vessels.
Results
The Intranodal vessels are located between the nodules of hyperplasia in the stroma of the gland, their average caliber is 340,2 µm (range 653-281 µm); the perinodal vessesl are located adjacent to the wall of each nodule of hyperplasia, whose average 128.4 µm (range 75-183 µm); finally, the intranodal vessels are located within each node of hyperplasia and it has an average diameter of 71.7 µm (range 63-102 µm)
Conclusions
The main objective in PAE for BPH is the occlusion of the vessels that supply the hyperplastic nodule to produce nodule reduction size improving the LUTS and avoiding collateral damage. In our study we conclude that the ideal size of the embolization particles should be between the average diameter of the perinodal and internodal vessels (100-300 µm)
Final ID
426
Type
Original Scientific Research-Poster Only
Authors
G Garategui1, M Onorati2, E Becher1, O Peralta3, R Garcia-Monaco4
Institutions
1Italian Hospital of Buenos Aires, Buenos Aires, CABA, 2Buenos Aires University, Buenos Aires, CABA, 3N/A, Buenos Aires, Argentina, 4Hospital Italiano De Buenos Aires, Buenos Aires, Argentina
Purpose
BackgroundThe Benign Prostatic Hyperplasia (BPH) is one of the most common disease in older men that can produce lower urinary tract symptoms (LUTS). In the last years, the Prostatic Arterial Embolization (PAE) gained relevance as a new and potential minimally invasive treatment. Nowadays there are not consensus about of the size of the embolization particle due to the lack of information about the caliber of the prostatic vessels. ObjectiveTo describe the microvasculature of the prostate gland and determine the caliber of the vessels, highlighting implications for the PAE in the BPH.
Materials & Methods
Eighteen adult cadaveric prostate gland with BPH were fixated in formaldehyde and processed histologically in three parts (superior, middle and inferior part). We focus only the parts of the gland that involves the transitional zone. Every sample was stained with hematoxylin and eosin, Masson trichrome and immunoperoxidase to highlight the vessels architecture. We analyzed the diameter of the vessels using Nikon Eclipse E400 Microscope, Nikkon DS-Fi1 Camera and Image J digital software. We classified three kind of vessels in relationship with de nodules of prostatic hyperplasia (NPH): the internodal, the perinodal and the intranodal vessels.
Results
The Intranodal vessels are located between the nodules of hyperplasia in the stroma of the gland, their average caliber is 340,2 µm (range 653-281 µm); the perinodal vessesl are located adjacent to the wall of each nodule of hyperplasia, whose average 128.4 µm (range 75-183 µm); finally, the intranodal vessels are located within each node of hyperplasia and it has an average diameter of 71.7 µm (range 63-102 µm)
Conclusions
The main objective in PAE for BPH is the occlusion of the vessels that supply the hyperplastic nodule to produce nodule reduction size improving the LUTS and avoiding collateral damage. In our study we conclude that the ideal size of the embolization particles should be between the average diameter of the perinodal and internodal vessels (100-300 µm)