REGULAR CONTENT
Final ID
423
Type
Original Scientific Research-Oral or Pos
Authors
D Kraitchman1, I Kamel2, C Weiss3, C Georgiades4
Institutions
1Johns Hopkins University, Baltimore, MD, 2Johns Hopkins Hospital, Baltimore, MD, 3N/A, Baltimore, MD, 4JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD
Purpose
The introduction of new lymphatic interventions has been slow, partly due to the lack of a large animal research model. Our objective was to define the percutaneously accessible, anatomically reproducible swine lymph nodes and correlate findings between MRI, ultrasound and lipiodol lymphangiography.
Materials & Methods
Five adult female swine (50-60Kg) we used. Under general anesthesia, T1- and T2-weighted, coronal and axial images of the entire swine were obtained from base of skull to groins. Then, the animal's extra-thoracic, extra-peritoneal soft tissues from the neck to the groins were scanned with ultrasound. Lymph nodes 1 cm or larger were marked before the animal was transferred to the angiography machine. Under ultrasound guidance, these nodes were accessed and lymphangiograms were obtained. The imaging findings between the three modalities were correlated and the lymph node drainage mapped.
Results
Four lymph nodes/lymph node groups were identified that were reproducible in all 5 animals, larger than 1 cm and percutaneously accessible. The submandibular node, the superficial cervical lymph node group, the subiliac node and the superficial inguinal lymph node group. Drainage of these nodes mirrored human anatomy. The abdominopelvic lymphatics formed a retroperitoneal cisterna chyli and drained cephalad via a thoracic duct.
Conclusions
The swine exhibits conserved lymphatic anatomy with at least four percutaneously accessible lymph nodes/node groups. Based on these results the swine may be a suitable large animal model for research into lymphatic interventions.
Final ID
423
Type
Original Scientific Research-Oral or Pos
Authors
D Kraitchman1, I Kamel2, C Weiss3, C Georgiades4
Institutions
1Johns Hopkins University, Baltimore, MD, 2Johns Hopkins Hospital, Baltimore, MD, 3N/A, Baltimore, MD, 4JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD
Purpose
The introduction of new lymphatic interventions has been slow, partly due to the lack of a large animal research model. Our objective was to define the percutaneously accessible, anatomically reproducible swine lymph nodes and correlate findings between MRI, ultrasound and lipiodol lymphangiography.
Materials & Methods
Five adult female swine (50-60Kg) we used. Under general anesthesia, T1- and T2-weighted, coronal and axial images of the entire swine were obtained from base of skull to groins. Then, the animal's extra-thoracic, extra-peritoneal soft tissues from the neck to the groins were scanned with ultrasound. Lymph nodes 1 cm or larger were marked before the animal was transferred to the angiography machine. Under ultrasound guidance, these nodes were accessed and lymphangiograms were obtained. The imaging findings between the three modalities were correlated and the lymph node drainage mapped.
Results
Four lymph nodes/lymph node groups were identified that were reproducible in all 5 animals, larger than 1 cm and percutaneously accessible. The submandibular node, the superficial cervical lymph node group, the subiliac node and the superficial inguinal lymph node group. Drainage of these nodes mirrored human anatomy. The abdominopelvic lymphatics formed a retroperitoneal cisterna chyli and drained cephalad via a thoracic duct.
Conclusions
The swine exhibits conserved lymphatic anatomy with at least four percutaneously accessible lymph nodes/node groups. Based on these results the swine may be a suitable large animal model for research into lymphatic interventions.