REGULAR CONTENT
Final ID
421
Type
Original Scientific Research-Oral or Pos
Authors
A Cortes1, H Nishiofuku2, A Minhaj1, K Maldonado1, K Dixon1, C Kingsley1, A Mcwatters1, K Kichikawa2, M Hicks1, R Avritscher1
Institutions
1The University of Texas MD Anderson Cancer Center, Houston, TX, 2Nara Medical University, Kashihara, Nara
Purpose
To investigate factors that impact technical success rate of transcatheter arterial chemoembolization in the most commonly used rodent model in interventional radiology research.
Materials & Methods
All studies were approved by our institutional animal care and use committee and were performed in accordance with institutional guidelines. Ninety-one adult male Sprague-Dawley rats underwent hepatic arterial catheterization using a left transcarotid approach and were divided into N1S1 tumor-bearing (n=50) and non-tumor bearing (n=41) groups. Diameter of the proper (PH), left (LH) and right hepatic (RH) arteries, presence of anatomic variants, and animal weight were recorded at the time of angiography. Technical success of the procedure was defined as the stable placement of the microcatheter tip into the PHA. Spearman's rank correlation coefficient (r) was calculated to determine the relationship between size of hepatic artery and weight of rats. Mann-Whitney and Wilcoxon tests were used to evaluate the differences between groups.
Results
There was a strong positive correlation between diameter of the PH and the weight of rats in non-tumor bearing group (r=0.65; P<0.0001) and a similar moderate association was observed in the tumor bearing group (r=0.40, P=0.004).The overall success rate was 81%. There was a significant difference in both the PH diameter and the weight of rats between successful and suboptimal PH catheterization (0.59 vs 0.44mm; P<0.0001, 337.9 vs 252.6 g; P<0.0001). The left hepatic artery was significantly larger in diameter compared with the right hepatic artery (P<0.0001).Variant of anatomy was observed in one case.
Conclusions
Rat weight positively correlates with proper hepatic artery diameter. Technical success rate is greater with PH diameters over 0.6 mm, typically present in animals weighing over 338 g. Familiarity with these factors can increase technical success rates of TACE in this rodent model.
Final ID
421
Type
Original Scientific Research-Oral or Pos
Authors
A Cortes1, H Nishiofuku2, A Minhaj1, K Maldonado1, K Dixon1, C Kingsley1, A Mcwatters1, K Kichikawa2, M Hicks1, R Avritscher1
Institutions
1The University of Texas MD Anderson Cancer Center, Houston, TX, 2Nara Medical University, Kashihara, Nara
Purpose
To investigate factors that impact technical success rate of transcatheter arterial chemoembolization in the most commonly used rodent model in interventional radiology research.
Materials & Methods
All studies were approved by our institutional animal care and use committee and were performed in accordance with institutional guidelines. Ninety-one adult male Sprague-Dawley rats underwent hepatic arterial catheterization using a left transcarotid approach and were divided into N1S1 tumor-bearing (n=50) and non-tumor bearing (n=41) groups. Diameter of the proper (PH), left (LH) and right hepatic (RH) arteries, presence of anatomic variants, and animal weight were recorded at the time of angiography. Technical success of the procedure was defined as the stable placement of the microcatheter tip into the PHA. Spearman's rank correlation coefficient (r) was calculated to determine the relationship between size of hepatic artery and weight of rats. Mann-Whitney and Wilcoxon tests were used to evaluate the differences between groups.
Results
There was a strong positive correlation between diameter of the PH and the weight of rats in non-tumor bearing group (r=0.65; P<0.0001) and a similar moderate association was observed in the tumor bearing group (r=0.40, P=0.004).The overall success rate was 81%. There was a significant difference in both the PH diameter and the weight of rats between successful and suboptimal PH catheterization (0.59 vs 0.44mm; P<0.0001, 337.9 vs 252.6 g; P<0.0001). The left hepatic artery was significantly larger in diameter compared with the right hepatic artery (P<0.0001).Variant of anatomy was observed in one case.
Conclusions
Rat weight positively correlates with proper hepatic artery diameter. Technical success rate is greater with PH diameters over 0.6 mm, typically present in animals weighing over 338 g. Familiarity with these factors can increase technical success rates of TACE in this rodent model.